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研究队伍

季光 主任医师、教授,博士研究生导师

主要研究领域:肝脏疾病证候分类基础和应用研究

主要研究方向:以脾主运化理论为指导,开展基于证候分类的中医药精准干预和转化研究以及代谢性疾病的中西医结合防治

代表性研究成果:

1. Li Y, Liu Y, Xu H, Jiang G, Van der Jeught K, Fang Y, Zhou Z, Zhang L, Frieden M, Wang L, Luo Z, Radovich M, Schneider BP, Deng Y, Liu Y, Huang K, He B, Wang J, He X, Zhang X, Ji G*, Lu X*. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Nat Commun. 2018 Oct 22;9(1):4394. doi: 10.1038/s41467-018-06811-z.

2. Van der Jeught K, Xu HC, Li YJ, Lu XB, Ji G*. Drug resistance and new therapies in colorectal cancer. World J Gastroenterol. 2018 Sep 14;24(34):3834-3848. doi: 10.3748/wjg.v24.i34.3834. Review.

3. Liu Y, Xu H, Van der Jeught K, Li Y, Liu S, Zhang L, Fang Y, Zhang X, Radovich M, Schneider BP, He X, Huang C, Zhang C, Wan J, Ji G*, Lu X*. Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. J Clin Invest. 2018 Jul 2;128(7):2951-2965. doi: 10.1172/JCI98727. Epub 2018 Jun 4

4. Zhu M, Wang Q, Zhou W, Liu T, Yang L, Zheng P, Zhang L, Ji G*. Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD. Sci Rep. 2018 May 16;8(1):7628.

5. Zheng YY, Wang M, Shu XB, Zheng PY, Ji G*. Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury. World J Gastroenterology. 2018 Mar 7; 24(9):992-1003.

6. Zheng Y, Wang M, Zheng P, Tang X, Ji G*. Systems pharmacology-based exploration reveals mechanisms of anti-steatotic effects of Jiang Zhi Granule on non-alcoholic fatty liver disease. Sci Rep. 2018 Sep 12;8(1):13681.

7. Wu T, Zheng X, Yang M, Zhao A, Li M, Chen T, Panee J, Jia W, Ji G*. Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients. Sci Rep. 2017 Feb 15;7:42710.

8. Li Fenghua#, Yang Yang#, Yang Lili, Wang Kai, Zhang Xing, Zong Yunlong, Ding Yixin, Wang Changhong, Zhang Li*, Ji Guang*, Resveratrol alleviates FFA and CCl4 induced apoptosis in HepG2 cells via restoring endoplasmic reticulum stress. Oncotarget, 2017, 8(27): 43799-43809.

9. Han Han, Li Yang, Yue Ding, Guang Ji*, Tong Zhang(*), Pharmacokinetics and metabolism profiles of protostemonine in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2016, 117: 266-275

10. Yu Zhang , Ming Gu, Wujie Cai, Lijing Yu, Li Feng, Lu Zhang, Qingqing Zang, Yahui Wang, Dongshan Wang, Hui Chen, Qingchun Tong*, Guang Ji*, Cheng Huang*, Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency, Scientific Reports, 2016, 5(19288):1-11

11. Li Zhang , Guang Ji*, Leptin and Non-Alcoholic Fatty Liver Disease: Hints From Preliminary Clinical Studies, International Journal of Digestive Diseases, 2015, 1(1): 1-3

12. Sui Hua# , Xu Hanchen#, Ji Qing, Liu Xuan, Zhou Lihong, Song Haiyan, Zhou Xiqiu, Xu Yangxian, Chen Zhesheng, Cai Jianfeng, Ji Guang* Li, Qi* , 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/beta-catenin/MMP-7 signaling pathway, Oncotarget, 2015, 6(28):25975-25987

13. Yu Zhang, Lijing Yu, Wujie Cai, Shenjie Fan, Li Feng, Guang Ji*, Cheng Huang(*), Protopanaxatriol, a novel PPARc antagonist from Panax ginseng,alleviates steatosis in mice, Scientific Reports, 2015, 4(7375): 1-12

14. Wu Tao, Xie Guoxiang, Ni Yan, Liu Tao, Yang Ming, Wei Hhuafeng, Jia Wei*, Ji G*, Serum Metabolite Signatures of Type 2 Diabetes Mellitus Complications., Journal of Proteome Research, 2015, 14 (1): 447-456

15. Yan Xie, Jingze Duan, Qingxue Fu, Mengxin Xia, Lei Zhang, Guowen Li, Tao Wu, Guang Ji*. Comparison of isorhamnetin absorption properties in total flavones of Hippophae rhamnoides L. with its pure form in a Caco-2 cell model mediated by multidrug resistance-associated protein. European Journal of Pharmaceutical Sciences, 2015,73:1-8

16. Tao Wu, Ming Yang, Tao Liu, Lili Yang, Guang Ji*, A Metabolomics Approach to Stratify Patients Diagnosed with Diabetes Mellitus into Excess or Deficiency Syndromes, Evidence-Based Complementary and Alternative Medicine, 2015, 2015:350703

17. Haiyan Song#, Jielu Pan#,Yang Liu, Hongzhu Wen, Lei Wang, Jiefeng Cai, Yinkun Liu, Bing Hu, Zemin Yao, Guang Ji* , Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma, International Journal of Molecular Sciences, 2015, 16 (1):178-192

18. Shu Xiangbing#, Zhang Li#, Ji Guang*, Vitamin E Therapy in Non-Alcoholic Fatty Liver Disease, International Journal of Clinical Medicine, 2014, 5: 87-92

19. Tao Wu, Tao Liu, Li Zhang, Lianjun Xing, Peiyong Zheng, Guang Ji*, Chinese medicinal formula, Qinggan Huoxue Recipe protects rats from alcoholic liver disease via the lipopolysaccharide Kupffer cell signal conduction pathway, Experimental and Therapeutic Medicine, 2014,8 (2): 363-370

20. Liu Yang#, Song Haiyan#, Wang Lei, Xu Hanchen, Shu Xiangbing, Zhang Li, Ji Guang*, Hepatoprotective and antioxidant activities of extracts from Salvia Nelumbinis naturalis against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet in mice, Journal of translational medicine, 2014, 12(1):31

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